Why does Full-spectrum CBD oil cost so much?

Why does Full-spectrum CBD oil cost so much?

 Full-Spectrum CBD Oil for a Full Spectrum of Benefits

Since the 2018 legalization of hemp-based CBD, CBD products have flooded the market and left consumers wondering what to look for in terms of quality. With so many products with various application methods to choose from, it is important to know what really counts when evaluating the potential effectiveness and even the safety of a CBD oil.

Many companies sell CBD isolates which are products with only the compound CBD present and no other substances extracted from the hemp plant. These products tout high percentages of CBD but often use a lot of fertilizers and pesticides along with cheap or unsafe processing methods that yield an oil that can be less effective and tainted. As with many things, it comes down to quality, not quantity. Though the promises of a “pure” product may be alluring, research has shown that users reap the most benefits and see the most results when using full-spectrum CBD oil such as Nature’s Daily Dose, which is produced from hemp that is grown on a USDA approved organic farm.

 

Full-spectrum CBD oil vs CBD isolate

Full-spectrum CBD oil has many benefits over CBD isolate which will be covered throughout this article. One of the most important downsides is the limited effectiveness of CBD isolate called the bell-shaped response curve. This effect, named for the graphic representation of the effectiveness of CBD isolate at different doses, explains one of its biggest downsides. At small and high doses, the effectiveness of CBD isolate decreases and tapers off. Its optimal, medium dosage for peak effectiveness is hard to pinpoint, which limits its usefulness for treating the variety of maladies CBD has the potential to ameliorate. This isn’t CBD isolate’s only weakness. This pure CBD extract also loses out on the other therapeutic compounds present in full-spectrum CBD which result in the highly beneficial entourage effect.

 

What Is the Entourage Effect?

The term “entourage effect” was coined in a 1999 study that suggested that the phenomenon explains why botanical drugs that contain the entire spectrum of compounds naturally produced in a plant are more effective than drugs that only use the plants’ isolated components. The entourage effect refers to the increased efficacy of CBD’s medicinal properties when other beneficial substances such as terpenes, enzymes, and other cannabinoids are present. These other substances facilitate the medicinal effects of CBD and provide benefits of their own. One of the primary reasons CBD works more effectively due to the entourage effect is that some of the other compounds are metabolized by the same enzymes as CBD. As a result, while these enzymes are busy breaking down other compounds, CBD is allowed to circulate and deliver its therapeutic effects throughout the body for a longer period.

 

The ability that full-spectrum CBD oil has to treat maladies using various compounds suggests a potential that cannot be overstated. When people seek relief from complex and multifaceted issues like anxiety, premenstrual syndrome, or depression, there are often multiple paths that lead to the same outcome and can provide specific or general relief. For example, as a treatment for depression, CBD can actively affect serotonin receptors while other compounds offer relief by affecting other neurotransmitters. The entourage effect shows that CBD’s effectiveness is closely tied to the other natural substances preserved in the hemp extract. These benefits are only present in products that extract these other compounds along with CBD, which is where a manufacturer’s extraction method plays an important role in determining the ultimate quality of CBD oil products

How does Nature’s Daily Dose offer the benefits of the Entourage Effect?

The secret lies in the extraction method. Nature’s Daily Dose is extracted using USDA Certified Organic food grade ethanol. This advanced technique yields a full-spectrum extract that includes only the desired terpenes and cannabinoids without pulling undesired substances such as wax and lipids. This method is also safer than other common techniques that use harsh chemicals such as butane and sometimes leave a residue in the final product. 

 

Other beneficial Cannabinoids in Nature’s Daily Dose

Cannabinoids are compounds that mimic chemicals naturally produced in the brain and body when they are plugged into the same receptors. They serve as hemp and marijuana’s active ingredients, and they are responsible for the medicinal benefits users seek. 

In addition to its high-quality CBD, Nature’s Daily Dose has high percentages of other highly beneficial cannabinoids, mainly cannabichromene(CBC), cannabigerol(CBG), and CBDA.

Studies of cannabichromene, or CBC have shown that it has powerful anti-inflammatory effects, even stronger than some anti-inflammatory pharmaceuticals such as Phenylbutazone. It has also shown strong antibacterial effects and mild to moderate antifungal effects. These properties of CBC in Nature’s Daily Dose make it a potentially powerful treatment aid for those seeking relief from inflammation while also preventing infections and fungal growth.

CBG is a common cannabinoid that is sometimes referred to as the “mother of all cannabinoids” because it is the precursor to other cannabinoids, including CBD. It’s a potentially useful antidepressant due to its ability to block serotonin receptors in the brain. Additionally, CBG is a GABA uptake inhibitor, so it also has the potential to reduce feelings of anxiety as well as relax muscle tension. Some research has also shown CBG’s potential as a glaucoma and inflammatory bowel disease treatment because it reduces inflammation. 

CBDA is another powerful cannabinoid included in Nature’s Daily Dose. It’s proven to bolster and supplement CBD’s ability to fight nausea and anxiety. It also works as a fantastic anti-inflammatory agent by targeting and inhibiting the COX-2 enzyme, which is the same one targeted by anti-inflammatory drugs such as aspirin and ibuprofen. This impressive cannabinoid has also shown promising potential as an anticancer agent. A 2012 study found that it was effective in inhibiting the growth of some forms of breast cancer, and that it could prevent breast cancer cells from migrating and moving to other parts of the body. Still, further research is needed to understand the mechanisms by which CBDA has these effects.

  

CBD’s boost from terpenes in Nature’s Daily Dose

Terpenes, which bolster the entourage effect, are the oils that give some plants like lemons and pine needles their characteristic smell. There are many terpenes extracted in Nature’s Daily Dose. These substances, like cannabinoids, seem to facilitate the effectiveness of CBD while also providing benefits of their own. One of the ways that terpenes increase the effectiveness of CBD is by increasing its bioavailability. On its own, CBD cannot travel or be absorbed throughout the body nearly as much as when it gets help from terpenoids. It makes sense, considering that some terpenoids found in cannabis extracts are so good at moving drugs across skin barriers, that they are added to dermatological products to help absorption.

The terpene present in the highest quantity in Nature’s Daily Dose is beta caryophyllene, which is known for giving black pepper its spicy zing. It was one of the first non-cannabinoids found to directly activate cannabinoid receptors in the brain. Due to beta caryophyllene’s interactions with CB2 receptors, it may offer a variety of benefits such as pain reduction. A study of this terpene’s effect on mice showed that it has some pain reducing effects, which bolsters CBD oil’s potential as a natural alternative to opioids and other strong pain-relieving medications. Other benefits of beta caryophyllene include possible protection from neurodegenerative disorders such as Alzheimer's.

Another terpene present in Nature’s Daily dose is epi-alpha-bisabolol. This terpene is used in a variety of essential oils for its proven anti-inflammatory effects, but it has also exhibited analgesic, antibiotic, and anticancer effects. Epi-alpha-Bisabolol’s usefulness for treating skin abrasions and irritation make it a popular additive to lotions, balms, and aftershave. 

A study of the effects of beta-Eudesmol, another terpene extracted in Nature’s Daily Dose on rats showed that the terpene caused an increase in appetite. Though further research is needed to understand the potential effects of this on humans, this points to a potential remedy for those struggling with dietary issues caused by eating disorders or other illnesses that affect appetite.

CBD oil is a promising treatment for people seeking non-pharmaceutical relief from mild to intense symptoms from a variety of maladies such as glaucoma, irritable bowel syndrome, anxiety, premenstrual syndrome, and depression. Though CBD is the star of the show, it can more efficiently deliver its effects with the help of the other cannabinoids and terpenes from the hemp plant that offer users relief and benefits of their own. Nature’s Daily Dose offers the full therapeutic potential of hemp extract with its ethanol extraction method. As unnecessary waxes and lipids are left behind, the ethanol extraction method safely delivers powerful medicinal compounds such as CBG, CBDA, and beta caryophyllene in the final product to boost and supplement CBD’s medicinal power. In addition, Nature’s Daily Dose’s USDA certified organic hemp means that users can rest assured that the oil they are using is free from any pesticides or fertilizers that could pose a risk to their health.

 

 

 

Works Cited:

Chan, Weng-Keong, et al. “Nerolidol: A Sesquiterpene Alcohol with Multi-Faceted Pharmacological and Biological Activities.” Molecules, vol. 21, no. 5, 2016, p. 529., doi:10.3390/molecules21050529.

Chen, Angus. “Some of the Parts: Is Marijuana's ‘Entourage Effect’ Scientifically Valid?” Scientific American, Scientific American, 20 Apr. 2017, www.scientificamerican.com/article/some-of-the-parts-is-marijuana-rsquo-s-ldquo-entourage-effect-rdquo-scientifically-valid/.

Gertsch, Jürg, et al. “Beta-Caryophyllene Is a Dietary Cannabinoid.” Proceedings of the National Academy of Sciences, vol. 105, no. 26, 2008, pp. 9099–9104., doi:10.1073/pnas.0803601105.

Kamatou, Guy P. P., and Alvaro M. Viljoen. “A Review of the Application and Pharmacological Properties of α-Bisabolol and α-Bisabolol-Rich Oils.” Journal of the American Oil Chemists' Society, vol. 87, no. 1, 2009, pp. 1–7., doi:10.1007/s11746-009-1483-3.

Katsuyama, S., et al. “Involvement of Peripheral Cannabinoid and Opioid Receptors in β-Caryophyllene-Induced Antinociception.” European Journal of Pain, vol. 17, no. 5, 2012, pp. 664–675., doi:10.1002/j.1532-2149.2012.00242.x.

Ohara, Kazuaki, et al. “β-Eudesmol, an Oxygenized Sesquiterpene, Stimulates Appetite via TRPA1 and the Autonomic Nervous System.” Scientific Reports, vol. 7, no. 1, 2017, doi:10.1038/s41598-017-16150-6.

Rogerio, Alexandre P., et al. “Preventive and Therapeutic Anti-Inflammatory Properties of the Sesquiterpene α-Humulene in Experimental Airways Allergic Inflammation.” British Journal of Pharmacology, vol. 158, no. 4, 2009, pp. 1074–1087., doi:10.1111/j.1476-5381.2009.00177.x.

Russo, Ethan B. “Taming THC: Potential Cannabis Synergy and Phytocannabinoid-Terpenoid Entourage Effects.” British Journal of Pharmacology, vol. 163, no. 7, 2011, pp. 1344–1364., doi:10.1111/j.1476-5381.2011.01238.x.

Russo, Ethan B. “The Case for the Entourage Effect and Conventional Breeding of Clinical Cannabis: No ‘Strain,’ No Gain.” Frontiers in Plant Science, vol. 9, 2019, doi:10.3389/fpls.2018.01969.

Sales, Amanda J., et al. “Antidepressant-like Effect Induced by Cannabidiol Is Dependent on Brain Serotonin Levels.” Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 86, 2018, pp. 255–261., doi:10.1016/j.pnpbp.2018.06.002.

Udoh, Michael, et al. “Cannabichromene Is a Cannabinoid CB            2            Receptor Agonist.” British Journal of Pharmacology, vol. 176, no. 23, 2019, pp. 4537–4547., doi:10.1111/bph.14815.

 


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